Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide.

Cartilage specimens from osteoarthritis (OA)-affected patients spontaneously released PGE2 at 48 h in ex vivo culture at levels at least 50-fold higher than in normal cartilage and 18-fold higher than in normal cartilage + cytokines + endotoxin. The superinduction of PGE2 production coincides with t...

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Pubblicato in:	J Clin Invest
Autori principali:	Amin, A R, Attur, M, Patel, R N, Thakker, G D, Marshall, P J, Rediske, J, Stuchin, S A, Patel, I R, Abramson, S B
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507937/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9077531/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119280
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