Resistance suppression by high-intensity, short-duration aminoglycoside exposure against hypermutable and non-hypermutable Pseudomonas aeruginosa

OBJECTIVES: Hypermutable bacteria are causing a drastic problem via their enhanced ability to become resistant. Our objectives were to compare bacterial killing and resistance emergence between differently shaped tobramycin concentration–time profiles at a given fAUC/MIC, and determine the tobramyci...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Rees, Vanessa E., Bulitta, Jürgen B., Oliver, Antonio, Tsuji, Brian T., Rayner, Craig R., Nation, Roger L., Landersdorfer, Cornelia B.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079302/
https://ncbi.nlm.nih.gov/pubmed/27521357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw297
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