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IFN-γ Induces Histone 3 Lysine 27 Trimethylation at a Small Subset of Promoters to Stably Silence Gene Expression in Human Macrophages
Mechanisms by which IFN-γ activates expression of interferon-stimulated genes that have inflammatory and host defense functions are well understood. In contrast, little is known about how IFN-γ represses gene expression. Using transcriptomic and epigenomic analysis we found that stable repression of...
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| Publicat a: | Cell Rep |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5079287/ https://ncbi.nlm.nih.gov/pubmed/27653678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.051 |
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