Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial

BACKGROUND: The clinical utility of molecular profiling of tumor tissue to guide treatment of patients with advanced solid tumors is unknown. Our objectives were to evaluate the frequency of genomic alterations, clinical “actionability” of somatic variants, enrollment in mutation-targeted or other c...

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Pubblicato in:Genome Med
Autori principali: Stockley, Tracy L., Oza, Amit M., Berman, Hal K., Leighl, Natasha B., Knox, Jennifer J., Shepherd, Frances A., Chen, Eric X., Krzyzanowska, Monika K., Dhani, Neesha, Joshua, Anthony M., Tsao, Ming-Sound, Serra, Stefano, Clarke, Blaise, Roehrl, Michael H., Zhang, Tong, Sukhai, Mahadeo A., Califaretti, Nadia, Trinkaus, Mateya, Shaw, Patricia, van der Kwast, Theodorus, Wang, Lisa, Virtanen, Carl, Kim, Raymond H., Razak, Albiruni R. A., Hansen, Aaron R., Yu, Celeste, Pugh, Trevor J., Kamel-Reid, Suzanne, Siu, Lillian L., Bedard, Philippe L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078968/
https://ncbi.nlm.nih.gov/pubmed/27782854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-016-0364-2
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