Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial

BACKGROUND: The clinical utility of molecular profiling of tumor tissue to guide treatment of patients with advanced solid tumors is unknown. Our objectives were to evaluate the frequency of genomic alterations, clinical “actionability” of somatic variants, enrollment in mutation-targeted or other c...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Stockley, Tracy L., Oza, Amit M., Berman, Hal K., Leighl, Natasha B., Knox, Jennifer J., Shepherd, Frances A., Chen, Eric X., Krzyzanowska, Monika K., Dhani, Neesha, Joshua, Anthony M., Tsao, Ming-Sound, Serra, Stefano, Clarke, Blaise, Roehrl, Michael H., Zhang, Tong, Sukhai, Mahadeo A., Califaretti, Nadia, Trinkaus, Mateya, Shaw, Patricia, van der Kwast, Theodorus, Wang, Lisa, Virtanen, Carl, Kim, Raymond H., Razak, Albiruni R. A., Hansen, Aaron R., Yu, Celeste, Pugh, Trevor J., Kamel-Reid, Suzanne, Siu, Lillian L., Bedard, Philippe L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078968/
https://ncbi.nlm.nih.gov/pubmed/27782854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-016-0364-2
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