Fluoxetine Prevents Aβ(1-42)-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-β1

Selective reuptake inhibitors (SSRIs), such as fluoxetine and sertraline, increase circulating Transforming-Growth-Factor-β1 (TGF-β1) levels in depressed patients, and are currently studied for their neuroprotective properties in Alzheimer’s disease. TGF-β1 is an anti-inflammatory cytokine that exer...

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Foilsithe in:Front Pharmacol
Main Authors: Caraci, Filippo, Tascedda, Fabio, Merlo, Sara, Benatti, Cristina, Spampinato, Simona F., Munafò, Antonio, Leggio, Gian Marco, Nicoletti, Ferdinando, Brunello, Nicoletta, Drago, Filippo, Sortino, Maria Angela, Copani, Agata
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2016
Ábhair:
Pharmacology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078904/
https://ncbi.nlm.nih.gov/pubmed/27826242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00389
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