Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1

Caloric restriction (CR) is known to retard aging and delay functional decline as well as the onset of diseases in most organisms. Ghrelin is secreted from the stomach in response to CR and regulates energy metabolism. We hypothesized that in CR ghrelin has a role in protecting aging-related disease...

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Detalhes bibliográficos
Publicado no:Mol Psychiatry
Main Authors: Fujitsuka, N, Asakawa, A, Morinaga, A, Amitani, M S, Amitani, H, Katsuura, G, Sawada, Y, Sudo, Y, Uezono, Y, Mochiki, E, Sakata, I, Sakai, T, Hanazaki, K, Yada, T, Yakabi, K, Sakuma, E, Ueki, T, Niijima, A, Nakagawa, K, Okubo, N, Takeda, H, Asaka, M, Inui, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078860/
https://ncbi.nlm.nih.gov/pubmed/26830139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.220
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