Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1

Caloric restriction (CR) is known to retard aging and delay functional decline as well as the onset of diseases in most organisms. Ghrelin is secreted from the stomach in response to CR and regulates energy metabolism. We hypothesized that in CR ghrelin has a role in protecting aging-related disease...

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Vydáno v:Mol Psychiatry
Hlavní autoři: Fujitsuka, N, Asakawa, A, Morinaga, A, Amitani, M S, Amitani, H, Katsuura, G, Sawada, Y, Sudo, Y, Uezono, Y, Mochiki, E, Sakata, I, Sakai, T, Hanazaki, K, Yada, T, Yakabi, K, Sakuma, E, Ueki, T, Niijima, A, Nakagawa, K, Okubo, N, Takeda, H, Asaka, M, Inui, A
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078860/
https://ncbi.nlm.nih.gov/pubmed/26830139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.220
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