Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth Through Disturbed Downstream TGF-β Signaling

Aneurysm-osteoarthritis syndrome characterized by unpredictable aortic aneurysm formation, is caused by SMAD3 mutations. SMAD3 is part of the SMAD2/3/4 transcription factor, essential for TGF-β-activated transcription. Although TGF-β-related gene mutations result in aneurysms, the underlying mechani...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: van der Pluijm, I., van Vliet, N., von der Thusen, J.H., Robertus, J.L., Ridwan, Y., van Heijningen, P.M., van Thiel, B.S., Vermeij, M., Hoeks, S.E., Buijs-Offerman, R.M.G.B., Verhagen, H.J.M., Kanaar, R., Bertoli-Avella, A.M., Essers, J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078606/
https://ncbi.nlm.nih.gov/pubmed/27688095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.09.006
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