Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth

Indoleamine 2,3-dioxygenase 2 (IDO2) is a newly discovered enzyme that catalyzes the initial and rate-limiting step in the degradation of tryptophan. As a homologous protein of IDO1, IDO2 plays an inhibitory role in T cell proliferation, and it is essential for regulatory T cell (Treg) generation in...

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Vydáno v:Oncotarget
Hlavní autoři: Liu, Yanling, Zhang, Yujuan, Zheng, Xiufen, Zhang, Xusheng, Wang, Hongmei, Li, Qin, Yuan, Keng, Zhou, Nanjing, Yu, Yanrong, Song, Na, Fu, Jiamin, Min, Weiping
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078016/
https://ncbi.nlm.nih.gov/pubmed/27058624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8617
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