Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction.

Interleukin-11 is a pleotropic cytokine produced by lung stromal cells in response to respiratory viruses, cytokines, and histamine. To further define its potential effector functions, the Clara cell 10-kD protein promoter was used to express IL-11 and the airways of the resulting transgene mice wer...

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Publicado en:J Clin Invest
Autores principales: Tang, W, Geba, G P, Zheng, T, Ray, P, Homer, R J, Kuhn, C, Flavell, R A, Elias, J A
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 1996
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Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507752/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8981933/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119113
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