Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity.

To investigate the contribution of interleukin-4 (IL-4) to airway inflammation in vivo and to explore directly its relationship to airway reactivity, we created transgenic mice in which the murine cDNA for IL-4 was regulated by the rat Clara cell 10 protein promoter. Expression was detected only in...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Rankin, J A, Picarella, D E, Geba, G P, Temann, U A, Prasad, B, DiCosmo, B, Tarallo, A, Stripp, B, Whitsett, J, Flavell, R A
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 1996
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38832/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8755560/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.15.7821
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