Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity.

To investigate the contribution of interleukin-4 (IL-4) to airway inflammation in vivo and to explore directly its relationship to airway reactivity, we created transgenic mice in which the murine cDNA for IL-4 was regulated by the rat Clara cell 10 protein promoter. Expression was detected only in...

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Autores principales: Rankin, J A, Picarella, D E, Geba, G P, Temann, U A, Prasad, B, DiCosmo, B, Tarallo, A, Stripp, B, Whitsett, J, Flavell, R A
Formato: Artigo
Lenguaje:Inglês
Publicado: 1996
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC38832/
https://ncbi.nlm.nih.gov/pubmed/8755560
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