Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes

MLL1 belongs to the SET1 family of histone H3 lysine 4 (H3K4) methyltransferases, composed of MLL1–4 and SETd1A/B. MLL1 translocations are present in acute leukemias, and mutations in several family members are associated with cancer and developmental disorders. MLL1 associates with a subcomplex con...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:J Biol Chem
المؤلفون الرئيسيون: Alicea-Velázquez, Nilda L., Shinsky, Stephen A., Loh, Daniel M., Lee, Jeong-Heon, Skalnik, David G., Cosgrove, Michael S.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2016
الموضوعات:
Gene Regulation
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077178/
https://ncbi.nlm.nih.gov/pubmed/27563068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752626
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