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Structural Basis for WDR5 Interaction (Win) Motif Recognition in Human SET1 Family Histone Methyltransferases

Translocations and amplifications of the mixed lineage leukemia-1 (MLL1) gene are associated with aggressive myeloid and lymphocytic leukemias in humans. MLL1 is a member of the SET1 family of histone H3 lysine 4 (H3K4) methyltransferases, which are required for transcription of genes involved in he...

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Main Authors: Dharmarajan, Venkatasubramanian, Lee, Jeong-Heon, Patel, Anamika, Skalnik, David G., Cosgrove, Michael S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431640/
https://ncbi.nlm.nih.gov/pubmed/22665483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.364125
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