Decoration of pH-sensitive copolymer micelles with tumor-specific peptide for enhanced cellular uptake of doxorubicin

To improve the targeting efficacy of hyaluronic acid (HA)-based micelles, pH-sensitive mixed micelles based on HA-g-poly(L-histidine) (PHis) and d-α-tocopheryl polyethylene glycol 2000 copolymers were prepared and decorated with human epidermal growth factor receptor 2 (Her2) peptide, a tumor cell-s...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Chen, Qing, Long, Miaomiao, Qiu, Lipeng, Zhu, Mengqin, Li, Zhen, Qiao, Mingxi, Hu, Haiyang, Zhao, Xiuli, Chen, Dawei
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077130/
https://ncbi.nlm.nih.gov/pubmed/27799766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S111950
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