Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass

Oncostatin M (OSM) and leukemia inhibitory factor (LIF) are IL-6 family members with a wide range of biological functions. Human OSM (hOSM) and murine LIF (mLIF) act in mouse cells via a LIF receptor (LIFR)-glycoprotein 130 (gp130) heterodimer. In contrast, murine OSM (mOSM) signals mainly via an OS...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Walker, Emma C., Johnson, Rachelle W., Hu, Yifang, Brennan, Holly J., Poulton, Ingrid J., Zhang, Jian-Guo, Jenkins, Brendan J., Smyth, Gordon K., Nicola, Nicos A., Sims, Natalie A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076839/
https://ncbi.nlm.nih.gov/pubmed/27539849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.748483
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