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Reversal of Phospholamban Inhibition of the Sarco(endo)plasmic Reticulum Ca(2+)-ATPase (SERCA) Using Short, Protein-interacting RNAs and Oligonucleotide Analogs
The sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) and phospholamban (PLN) complex regulates heart relaxation through its removal of cytosolic Ca(2+) during diastole. Dysfunction of this complex has been related to many heart disorders and is therefore a key pharmacological target. There are cur...
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| Veröffentlicht in: | J Biol Chem |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5076822/ https://ncbi.nlm.nih.gov/pubmed/27531746 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738807 |
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