Neuronal NCX1 overexpression induces stroke resistance while knockout induces vulnerability via Akt

Three different Na(+)/Ca(2+) exchanger (NCX) isoforms, NCX1, NCX2, and NCX3, are expressed in brain where they play a relevant role in maintaining Na(+) and Ca(2+) homeostasis. Although the neuroprotective roles of NCX2 and NCX3 in stroke have been elucidated, the relevance of NCX1 is still unknown...

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Bibliografiske detaljer
Udgivet i:J Cereb Blood Flow Metab
Main Authors: Molinaro, Pasquale, Sirabella, Rossana, Pignataro, Giuseppe, Petrozziello, Tiziana, Secondo, Agnese, Boscia, Francesca, Vinciguerra, Antonio, Cuomo, Ornella, Philipson, Kenneth D, De Felice, Mario, Di Lauro, Roberto, Di Renzo, Gianfranco, Annunziato, Lucio
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2015
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076784/
https://ncbi.nlm.nih.gov/pubmed/26661211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X15611913
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