Osteopontin is produced by rat cardiac fibroblasts and mediates A(II)-induced DNA synthesis and collagen gel contraction.

Angiotensin II (AII) is a critical factor in cardiac remodeling which involves hypertrophy, fibroblast proliferation, and extracellular matrix production. However, little is known about the mechanism by which AII accelerates these responses. Osteopontin is an acidic phosphoprotein with RGD (arginine...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Ashizawa, N, Graf, K, Do, Y S, Nunohiro, T, Giachelli, C M, Meehan, W P, Tuan, T L, Hsueh, W A
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1996
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507670/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8941637/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119031
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