Osteopontin is produced by rat cardiac fibroblasts and mediates A(II)-induced DNA synthesis and collagen gel contraction.

Angiotensin II (AII) is a critical factor in cardiac remodeling which involves hypertrophy, fibroblast proliferation, and extracellular matrix production. However, little is known about the mechanism by which AII accelerates these responses. Osteopontin is an acidic phosphoprotein with RGD (arginine...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Ashizawa, N, Graf, K, Do, Y S, Nunohiro, T, Giachelli, C M, Meehan, W P, Tuan, T L, Hsueh, W A
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507670/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8941637/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119031
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