Functional Rescue of a Misfolded Drosophila melanogaster Dopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones

Folding-defective mutants of the human dopamine transporter (DAT) cause a syndrome of infantile dystonia/parkinsonism. Here, we provide a proof-of-principle that the folding deficit is amenable to correction in vivo by two means, the cognate DAT ligand noribogaine and the HSP70 inhibitor, pifithrin-...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Kasture, Ameya, El-Kasaby, Ali, Szöllősi, Daniel, Asjad, H. M. Mazhar, Grimm, Alexandra, Stockner, Thomas, Hummel, Thomas, Freissmuth, Michael, Sucic, Sonja
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076501/
https://ncbi.nlm.nih.gov/pubmed/27481941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.737551
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