Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart.

The alpha-myosin heavy chain (alpha-MyHC) is the major contractile protein expressed in the myocardium of adult mice. We have produced mice carrying a null mutation of alpha-MyHC by homologous recombination in murine ES cells. Homozygous null animals die between 11 and 12 d in utero of gross heart d...

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Main Authors: Jones, W K, Grupp, I L, Doetschman, T, Grupp, G, Osinska, H, Hewett, T E, Boivin, G, Gulick, J, Ng, W A, Robbins, J
Format: Artigo
Sprog:Inglês
Udgivet: 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC507631/
https://ncbi.nlm.nih.gov/pubmed/8878443
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