Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription.

In normal subjects and diabetic patients, insulin suppresses whole body proteolysis suggesting that the loss of lean body mass and muscle wasting in insulinopenia is related to increased muscle protein degradation. To document how insulinopenia affects organ weights and to identify the pathway for a...

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Pubblicato in:	J Clin Invest
Autori principali:	Price, S R, Bailey, J L, Wang, X, Jurkovitz, C, England, B K, Ding, X, Phillips, L S, Mitch, W E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507607/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8878419/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118968
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