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Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription.

In normal subjects and diabetic patients, insulin suppresses whole body proteolysis suggesting that the loss of lean body mass and muscle wasting in insulinopenia is related to increased muscle protein degradation. To document how insulinopenia affects organ weights and to identify the pathway for a...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Price, S R, Bailey, J L, Wang, X, Jurkovitz, C, England, B K, Ding, X, Phillips, L S, Mitch, W E
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 1996
Konular:
Online Erişim:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507607/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8878419/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118968
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