Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs

In the human endocrine system many protein hormones including urotensin, glucagon, obestatin, bombesin and secretin, among others, are supplied from amyloidal secretory granules. These granules form part of the so called functional amyloids, which within the whole aggregome appear to be more abundan...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Céspedes, María Virtudes, Fernández, Yolanda, Unzueta, Ugutz, Mendoza, Rosa, Seras-Franzoso, Joaquin, Sánchez-Chardi, Alejando, Álamo, Patricia, Toledo-Rubio, Verónica, Ferrer-Miralles, Neus, Vázquez, Esther, Schwartz, Simó, Abasolo, Ibane, Corchero, José Luis, Mangues, Ramon, Villaverde, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075894/
https://ncbi.nlm.nih.gov/pubmed/27775083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35765
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