Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.

Aggregation and retention of LDL in the arterial wall are key events in atherogenesis, but the mechanisms in vivo are not known. Previous work from our laboratories has shown that exposure of LDL to bacterial sphingomyelinase (SMase) in vitro leads to the formation of LDL aggregates that can be reta...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Schissel, S L, Tweedie-Hardman, J, Rapp, J H, Graham, G, Williams, K J, Tabas, I
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507573/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8823312/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118934
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