Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.

Aggregation and retention of LDL in the arterial wall are key events in atherogenesis, but the mechanisms in vivo are not known. Previous work from our laboratories has shown that exposure of LDL to bacterial sphingomyelinase (SMase) in vitro leads to the formation of LDL aggregates that can be reta...

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Argitaratua izan da:	J Clin Invest
Egile Nagusiak:	Schissel, S L, Tweedie-Hardman, J, Rapp, J H, Graham, G, Williams, K J, Tabas, I
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	American Society for Clinical Investigation 1996
Gaiak:	Research Article
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507573/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8823312/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118934
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