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Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase

The tuberculosis drug bedaquiline inhibits mycobacterial F-ATP synthase by binding to its c subunit. Using the purified ε subunit of the synthase and spectroscopy, we previously demonstrated that the drug interacts with this protein near its unique tryptophan residue. Here, we show that replacement...

詳細記述

保存先:
書誌詳細
出版年:Antimicrob Agents Chemother
主要な著者: Kundu, Subhashri, Biukovic, Goran, Grüber, Gerhard, Dick, Thomas
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075122/
https://ncbi.nlm.nih.gov/pubmed/27620476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01291-16
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