Novel analog of atrial natriuretic peptide selective for receptor-A produces increased diuresis and natriuresis in rats.

Atrial natriuretic peptide (ANP) binds to natriuretic peptide receptor-A (NPR-A), a membrane guanylyl cyclase, and to natriuretic peptide receptor-C (NPR-C), which plays a role in peptide clearance. Rat ANP (rANP) mutants that bind rat NPR-A selectively over rat NPR-C were isolated from randomized l...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Jin, H, Li, B, Cunningham, B, Tom, J, Yang, R, Sehl, P, Thomas, G R, Ko, A, Oare, D, Lowe, D G
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 1996
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507512/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8770869/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118881
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