Population Pharmacokinetics and Safety of Ceftolozane-Tazobactam in Adult Cystic Fibrosis Patients Admitted with Acute Pulmonary Exacerbation

Ceftolozane-tazobactam has potent activity against Pseudomonas aeruginosa, a pathogen associated with cystic fibrosis (CF) acute pulmonary exacerbations (APE). Due to the rapid elimination of many antibiotics, CF patients frequently have altered pharmacokinetics. In this multicenter, open-label stud...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Monogue, Marguerite L., Pettit, Rebecca S., Muhlebach, Marianne, Cies, Jeffrey J., Nicolau, David P., Kuti, Joseph L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Clinical Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075062/
https://ncbi.nlm.nih.gov/pubmed/27550351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01566-16
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