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Selection Transforms the Landscape of Genetic Variation Interacting with Hsp90

The protein-folding chaperone Hsp90 has been proposed to buffer the phenotypic effects of mutations. The potential for Hsp90 and other putative buffers to increase robustness to mutation has had major impact on disease models, quantitative genetics, and evolutionary theory. But Hsp90 sometimes contr...

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Bibliografske podrobnosti
izdano v:PLoS Biol
Main Authors: Geiler-Samerotte, Kerry A., Zhu, Yuan O., Goulet, Benjamin E., Hall, David W., Siegal, Mark L.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074785/
https://ncbi.nlm.nih.gov/pubmed/27768682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2000465
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