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Selection Transforms the Landscape of Genetic Variation Interacting with Hsp90

The protein-folding chaperone Hsp90 has been proposed to buffer the phenotypic effects of mutations. The potential for Hsp90 and other putative buffers to increase robustness to mutation has had major impact on disease models, quantitative genetics, and evolutionary theory. But Hsp90 sometimes contr...

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Publicado en:PLoS Biol
Autores principales: Geiler-Samerotte, Kerry A., Zhu, Yuan O., Goulet, Benjamin E., Hall, David W., Siegal, Mark L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074785/
https://ncbi.nlm.nih.gov/pubmed/27768682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2000465
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