Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells.

Vascular endothelial growth factor (VEGF) potently stimulates angiogenesis, whereas TNF-alpha has both pro- and anti-angiogenic activity. By measuring thymidine uptake, we found that TNF-alpha blocked a 2.3-fold increase in DNA synthesis induced by VEGF in human endothelial cells. To explore the pos...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Patterson, C, Perrella, M A, Endege, W O, Yoshizumi, M, Lee, M E, Haber, E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507454/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8755661/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118816
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