The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling

Pressure overload is a frequent cause of heart failure. Heart failure affects millions of patients worldwide and is a major cause of morbidity and mortality. Cell surface proteoglycans are emerging as molecular players in cardiac remodeling, and increased knowledge about their regulation and functio...

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Udgivet i:PLoS One
Main Authors: Melleby, Arne O., Strand, Mari E., Romaine, Andreas, Herum, Kate M., Skrbic, Biljana, Dahl, Christen P., Sjaastad, Ivar, Fiane, Arnt E., Filmus, Jorge, Christensen, Geir, Lunde, Ida G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074531/
https://ncbi.nlm.nih.gov/pubmed/27768722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165079
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