Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis

A variety of commercial analogs and a newer series of Sulindac derivatives were screened for inhibition of M. tuberculosis (Mtb) in vitro and specifically as inhibitors of the essential mycobacterial tubulin homolog, FtsZ. Due to the ease of preparing diverse analogs and a favorable in vivo pharmaco...

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Bibliographic Details
Published in:PLoS One
Main Authors: Mathew, Bini, Hobrath, Judith Varady, Ross, Larry, Connelly, Michele C., Lofton, Hava, Rajagopalan, Malini, Guy, R. Kiplin, Reynolds, Robert C.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074515/
https://ncbi.nlm.nih.gov/pubmed/27768711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164100
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