Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis

A variety of commercial analogs and a newer series of Sulindac derivatives were screened for inhibition of M. tuberculosis (Mtb) in vitro and specifically as inhibitors of the essential mycobacterial tubulin homolog, FtsZ. Due to the ease of preparing diverse analogs and a favorable in vivo pharmaco...

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Опубликовано в: :PLoS One
Главные авторы: Mathew, Bini, Hobrath, Judith Varady, Ross, Larry, Connelly, Michele C., Lofton, Hava, Rajagopalan, Malini, Guy, R. Kiplin, Reynolds, Robert C.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074515/
https://ncbi.nlm.nih.gov/pubmed/27768711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164100
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