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Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis

A variety of commercial analogs and a newer series of Sulindac derivatives were screened for inhibition of M. tuberculosis (Mtb) in vitro and specifically as inhibitors of the essential mycobacterial tubulin homolog, FtsZ. Due to the ease of preparing diverse analogs and a favorable in vivo pharmaco...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Mathew, Bini, Hobrath, Judith Varady, Ross, Larry, Connelly, Michele C., Lofton, Hava, Rajagopalan, Malini, Guy, R. Kiplin, Reynolds, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074515/
https://ncbi.nlm.nih.gov/pubmed/27768711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164100
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