Duloxetine Inhibits Microglial P2X4 Receptor Function and Alleviates Neuropathic Pain after Peripheral Nerve Injury

P2X4 receptors (P2X4R) are a family of ATP-gated non-selective cation channels. We previously demonstrated that activation of P2X4R in spinal microglia is crucial for neuropathic pain, a highly debilitating chronic pain condition, suggesting that P2X4R is a potential therapeutic target for treating...

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Veröffentlicht in:PLoS One
Hauptverfasser: Yamashita, Tomohiro, Yamamoto, Shota, Zhang, Jiaming, Kometani, Miho, Tomiyama, Daisuke, Kohno, Keita, Tozaki-Saitoh, Hidetoshi, Inoue, Kazuhide, Tsuda, Makoto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074465/
https://ncbi.nlm.nih.gov/pubmed/27768754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165189
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