Leishmania uses Mincle to target an inhibitory ITAM signaling pathway in dendritic cells that dampens adaptive immunity to infection

C-type lectin receptors sense a diversity of endogenous and exogenous ligands that may trigger differential responses. Here, we have found that human and mouse Mincle bind to a ligand released by Leishmania, a eukaryote parasite that evades an effective immune response. Mincle-deficient mice had mil...

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Veröffentlicht in:Immunity
Hauptverfasser: Iborra, Salvador, Martínez-López, María, Cueto, Francisco J., Conde-Garrosa, Ruth, Del Fresno, Carlos, Izquierdo, Helena M., Abram, Clare L., Mori, Daiki, Campos-Martín, Yolanda, Reguera, Rosa María, Kemp, Benjamin, Yamasaki, Sho, Robinson, Matthew J., Soto, Manuel, Lowell, Clifford A., Sancho, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074365/
https://ncbi.nlm.nih.gov/pubmed/27742545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.09.012
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