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Mechanism of free fatty acid-induced insulin resistance in humans.

To examine the mechanism by which lipids cause insulin resistance in humans, skeletal muscle glycogen and glucose-6-phosphate concentrations were measured every 15 min by simultaneous 13C and 31P nuclear magnetic resonance spectroscopy in nine healthy subjects in the presence of low (0.18 +/- 0.02 m...

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Bibliographic Details
Main Authors: Roden, M, Price, T B, Perseghin, G, Petersen, K F, Rothman, D L, Cline, G W, Shulman, G I
Format: Artigo
Language:Inglês
Published: 1996
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC507380/
https://ncbi.nlm.nih.gov/pubmed/8675698
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