טוען...

Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures.

We have previously hypothesized that the pro-inflammatory cytokine TNF alpha has a pivotal role in the pathogenesis of rheumatoid arthritis (RA). It mediates its effects by cross-linking surface p55 TNF receptors (TNF-R), which can be proteolytically cleaved to yield soluble fragments. Upon binding...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Williams, L M, Gibbons, D L, Gearing, A, Maini, R N, Feldmann, M, Brennan, F M
פורמט: Artigo
שפה:Inglês
יצא לאור: 1996
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC507377/
https://ncbi.nlm.nih.gov/pubmed/8675695
תגים: הוספת תג
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