Dissociation of TNF-alpha cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-alpha mutants.

Human tumour necrosis factor alpha (TNF-alpha) is a pleiotropic cytokine capable of killing mammalian tumour cells in vitro and in vivo, and of enhancing the proinflammatory activity of leucocytes and endothelium, the latter effects limiting its usage as an antitumour agent in humans. Using TNF-alph...

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Detalhes bibliográficos
Main Authors: Barbara, J A, Smith, W B, Gamble, J R, Van Ostade, X, Vandenabeele, P, Tavernier, J, Fiers, W, Vadas, M A, Lopez, A F
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC394883/
https://ncbi.nlm.nih.gov/pubmed/7509279
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