Dissociation of TNF-alpha cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-alpha mutants.

Human tumour necrosis factor alpha (TNF-alpha) is a pleiotropic cytokine capable of killing mammalian tumour cells in vitro and in vivo, and of enhancing the proinflammatory activity of leucocytes and endothelium, the latter effects limiting its usage as an antitumour agent in humans. Using TNF-alph...

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Detalles Bibliográficos

Publicado en:	EMBO J
Principais autores:	Barbara, J A, Smith, W B, Gamble, J R, Van Ostade, X, Vandenabeele, P, Tavernier, J, Fiers, W, Vadas, M A, Lopez, A F
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 1994
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394883/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7509279/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06327.x
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