Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis.

Prostaglandins formed by the cyclooxygenase (COX) enzymes are important mediators of inflammation in arthritis. The contribution of the inducible COX-2 enzyme to inflammation in rat adjuvant arthritis was evaluated by characterization of COX-2 expression in normal and arthritic paws and by pharmacol...

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Publicat a:J Clin Invest
Autors principals: Anderson, G D, Hauser, S D, McGarity, K L, Bremer, M E, Isakson, P C, Gregory, S A
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1996
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507355/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8647962/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118717
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