P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

The mouse mdr1a (also called mdr3) P-GP is abundant in the blood-brain barrier, and its absence in mdr1a (-/-) mice leads to highly increased levels of the drugs ivermectin, vinblastine, digoxin, and cyclosporin A in the brain. We show here that the drugs loperamide, domperidone, and ondansetron are...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Schinkel, A H, Wagenaar, E, Mol, C A, van Deemter, L
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 1996
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507337/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8647944/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118699
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki