P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

The mouse mdr1a (also called mdr3) P-GP is abundant in the blood-brain barrier, and its absence in mdr1a (-/-) mice leads to highly increased levels of the drugs ivermectin, vinblastine, digoxin, and cyclosporin A in the brain. We show here that the drugs loperamide, domperidone, and ondansetron are...

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Pubblicato in:	J Clin Invest
Autori principali:	Schinkel, A H, Wagenaar, E, Mol, C A, van Deemter, L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507337/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8647944/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118699
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