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Antigen Targeting to Human HLA Class II Molecules Increases Efficacy of DNA Vaccination

It has been difficult to translate promising results from DNA vaccination in mice to larger animals and humans. Previously, DNA vaccines encoding proteins that target Ag to MHC class II (MHC-II) molecules on APCs have been shown to induce rapid, enhanced, and long-lasting Ag-specific Ab titers in mi...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Grodeland, Gunnveig, Fredriksen, Agnete Brunsvik, Løset, Geir Åge, Vikse, Elisabeth, Fugger, Lars, Bogen, Bjarne
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5073356/
https://ncbi.nlm.nih.gov/pubmed/27671110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600893
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