Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-kappa(B). Implications for FK506 nephropathy.

FK506 is a powerful immunosuppressive drug currently in use that inhibits the activation of several transcription factors (nuclear factor (NF)-AT and NF-kappaB) critical for T cell activation. We show here that, contrary to the situation in T cells, FK506 activates transcription factor NF-kappaB in...

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Detalhes bibliográficos
Main Authors: Muraoka, K, Fujimoto, K, Sun, X, Yoshioka, K, Shimizu, K, Yagi, M, Bose, H, Miyazaki, I, Yamamoto, K
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC507328/
https://ncbi.nlm.nih.gov/pubmed/8647935
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