Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice.

The regulation of liver apolipoprotein (apo) A-I gene expression by fibrates was studied in human apo A-I transgenic mice containing a human genomic DNA fragment driving apo A-I expression in liver. Treatment with fenofibrate (0.5% wt/wt) for 7 d increased plasma human apo A-I levels up to 750% and...

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Pubblicato in:	J Clin Invest
Autori principali:	Berthou, L, Duverger, N, Emmanuel, F, Langouët, S, Auwerx, J, Guillouzo, A, Fruchart, J C, Rubin, E, Denèfle, P, Staels, B, Branellec, D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507325/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8647932/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118687
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