Blockade of interleukin-27 signaling reduces GVHD in mice by augmenting Treg reconstitution and stabilizing Foxp3 expression

Reestablishment of competent regulatory pathways has emerged as a strategy to reduce the severity of graft-versus-host disease (GVHD), and recalibrate the effector and regulatory arms of the immune system. However, clinically feasible, cost-effective strategies that do not require extensive ex vivo...

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Vydáno v:Blood
Hlavní autoři: Belle, Ludovic, Agle, Kimberle, Zhou, Vivian, Yin-Yuan, Cheng, Komorowski, Richard, Eastwood, Daniel, Logan, Brent, Sun, Jie, Ghilardi, Nico, Cua, Daniel, Williams, Calvin B., Gaignage, Melanie, Marillier, Reece, van Snick, Jacques, Drobyski, William R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2016
Témata:
Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5073185/
https://ncbi.nlm.nih.gov/pubmed/27488350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-02-698241
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